1) Kambo Cleanse
Kambo is known for its intense and immediate purgatory effects that generally result in vomiting and diarrhea that can last up to 4 hours, which may remove toxins from the body. The ritual, performed by both tribes and urban people, has been documented and described in detail. Several peptides in Kambo are probably responsible for the effect
The phylloceruelean peptide in Kambo increased acid production in the stomach, contracted the small intestine, and increased pancreas activity
Stomach acid production was also increased by phylloceruleean
Additionally, the peptide phyllomedusin led to stomach spasms
2) Kambo May Help Relieve Stress and Anxiety
Kambo users frequently report improved mood. The Kambo peptide, dermorphin, decreased blood levels of the "stress hormone" cortisol in 28 healthy human subjects
A synthetic dermorphin reduced pain and anxiety in rats under stress after several days of repeated use
Deltorphins experienced an increase in overall movement and social interactions, which points to a decrease in anxiety 3) Kambo Relieves Pain
Deltorphin and dermorphin, found in the skin of the Amazon frog (Phyllomedusa bicolor
and other related species), are opioid peptides with promising pain-relieving effectsand minimal toxicity
Deltorphin peptides relieved pain by acting opioid-like (via delta-opioid receptors)
Deltorphin also relieved pain with chronic inflammation
Studies in cow brain blood vessels show deltorphin is able to cross the blood-brain barrier. This is important in order for the peptides to have an effect on the brain and reduce pain
Many research efforts are directed toward discovering peptides similar to deltorphin for the treatment of pain
Since dermorphin also relieves pain (but via mu-opioid receptors), researchers are aiming to optimize dermorphin as a safe alternative to morphine 4) Kambo Has Anticancer Properties
Dermaseptin B2, one of many peptides found in Kambo, blocked the growth of prostate cancer by promoting cell death
Dermaseptin B2 also stopped the growth of many human cancers in cell studies, including mouth cancer, prostate cancer, and brain tumors
Additionally, in cellular studies, Dermaseptin B2 blocked processes that led to new blood vessel growth, which is useful in treating cancer because it blocks the flow of nutrients to growing tumors
When nanoparticles were used to deliver dermaseptin to cancer cells, it had a stronger anticancer effect 5) Kambo May Help Treat Addiction
Tachykinins are small proteins that affect reward, motivation, and stress responses in the brain, which are disrupted in addiction. Molecules that can reach the brain and increase tachykinin activity (by binding to receptors) have the potential for treating addiction
Phyllomedusin is one tachykinin found in Kambo that is likely responsible for the effects of Kambo in treating addiction 6) Kambo Lowers Blood Pressure
Kambo users commonly report a drop in blood pressure as one of their symptoms during the initial unpleasant phase of Kambo cleansing. Two peptides found in Kambo (phylloceruelean and a physalaemin-like peptide) lowered blood pressure 7) Kambo May Protect the Heart
Deltorphin II, one of the peptides from Kambo, had increased blood flow to the heart, which prevented irregular heartbeat. This peptide is being researched as a new treatment for heart attacks 8) Kambo Is Antimicrobial
Many of the peptides found in the secretions of the tree frog can fight microbes, which protect the frog from infections. They have a wide spectrum of microbe-fighting activity
Adenoregulin fights both fungus and bacteria and is especially effective against E. coli
Dermaseptins are another class of peptides found in Kambo that kill both gram positive and gram negative bacteria as well as yeast.
Dermaspetin is also antiviral. It killed the herpes virus in cell studies but must be applied before the virus binds to host cells.
Biofilm infections are notoriously resistant and difficult to treat, often requiring high doses of antibiotics over a long duration. Dermaseptins stopped biofilm growth and were less toxic to cells than antibiotics.
Another peptide from Kambo, Phyllospetin-1, can also fight infections. It is especially potent against a bacteria that commonly cause skin infections (Staphylococcus aureus);and its associated biofilm.
Written by Chelsea Paresi, PhD (biomedical science)