Tradition and science behind Ayahuasca vine macrodosing:

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APL Shamanic Journeys retreats blog

Is Ayahuasca vine Macrodosing traditionally done in the Amazon?

In the Amazon, one of the main practices for healing, initiating and educating is called La Dieta. During this process, a patient lives in solitude with dietary and social restrictions. The patient takes one of the master (teacher) plants to receive healing and knowledge.

The rainforest is home to hundreds of master plants. The most well known one is called "mother of all medicine" or ayahuasca. This is the vine banisteriopsis caapi. There are shamans who use only the pure ayahuasca vine for ceremonies and healing. They believe that there is no better way to experience the medicinal properties of ayahuasca than with a dieta or by microdosing.

What science says about Ayahuasca vine dieta (Banisteriopsis caapi)?

Macrodosing with the ayahuasca vine is based not only on its traditional use, but also on solid scientific research undertaken these last few decades.

Researchers have identified the three main alkaloids in the ayahuasca vine that are responsible for the effectiveness of the brew. These alkaloids are the b-carbolines harmine, harmaline and tetrahydroharmine. In vitro, these b-carbolines have demonstrated powerful activity against monoamine oxidase (MAO)-A and certain enzymes in the human brain. Hence they are MAO-inhibitors (MAOIs). These b-carbolines also stimulate the release of dopamine.

Proanthocyanidins, epicatechin and procyanidin are also present in banisteriopsis caapi and show MAO-B inhibitory activity. Their antioxidant properties help to protect nerve cells from oxidative free radicals.

B-carbolines in our body mainly target enzymes of monoamine oxidase (MAO) that break down and regulate neurotransmitters such as dopamine and serotonin. B-carbolines also affect other neurotransmitter receptors such as DYRK1A, 5HT2a, 5HT2c, I2R, and DAT.

What is special about APL's Macrodosing dieta
with Ayahuasca vine?

Our course is based on scientific as well as traditional understanding of Amazonian dietas.

Other sellers may propose taking only a few drops daily, but we derived from scientific research that ayahuasca can never be effective in such small quantities.

The alkaloids responsible for b.caapi's effectiveness are the b-carbolines harmine, harmaline and tetrahydroharmine. These are MAOIs which implies some restrictions described further below. To determine the optimal dosage of the b.caapi extract, we must first ascertain the content of these alkaloids in the brew. Different studies have been conducted on this matter. We started from Dennis McKenna's 1984 study and Jonathan Ott's Pharmacology of Oral DMT Plus Harmine.

From this we learned that the total content of b-carbolines in a typical ayahuasca brew is 6,68%:

Harmine - 4,67%
Harmaline - 0,41%
Tetrahydroharmine. - 1,6%

Research established that 1 mg of harmine per kg of bodyweight is the minimum effective dose. For example, if your weight is 70 kg, your minimum daily portion of harmine is 70 mg.

We advise taking 24 ml of ayahuasca daily for the duration of the course. This macrodose will contain around 112 mg of harmine. Microdoses proposed by other providers will only contain between 4.67 and 30 mg of harmine.

This is how we assure the effectiveness of our ayahuasca macrodosing course.

Is it safe to take pure Ayahuasca vine without a shaman?

APL Shamanic Journeys is known to take ayahuasca ceremonies very seriously. APL only work with traditional shamans from the Amazon who passed the necessary training by dieting in the rainforest with master plants.

Our ayahuasca macrodosing course does not contain plants with DMT such as psychotria viridis. It is made with 100 % B.caapi, the Ayahuasca vine.

This type of Ayahuasca has a long tradition of use in the Amazon in the form of a tea and does not cause an altered state of consciousness if used in moderate amount.
This is why it is completely safe so self-administer without guidance.

Is Ayahuasca vine legal in my country?

Ayahuasca vine is completely legal to possess in the European Union and Great Britain, (with the exception of France, Lithuania, Poland and Réunion) and the United States (except the State of Louisiana).

If you live outside these countries please consult your customs authorities before placing the order. B-carbolins, such as harmine, harmaline and tetrohydroharmine should be legal in your country as well as the banisteriopsis caapi vine itself.

Unfortunately, due to legislation we cannot ship this product to the following countries:
Australia, Canada, France, Lithuania, Poland, Réunion, the Russian Federation and Ukraine.
Ayahuasca vine is completely legal to possess in the European Union and Great Britain, (with the exception of France, Lithuania, Poland and Réunion) and the United States (except the State of Louisiana).

If you live outside these countries please consult your customs authorities before placing the order. B-carbolins, such as harmine, harmaline and tetrohydroharmine should be legal in your country as well as the banisteriopsis caapi vine itself.

Unfortunately, due to legislation we cannot ship this product to the following countries:
Australia, Canada, France, Lithuania, Poland, Réunion, the Russian Federation and Ukraine.