The main challenge that the b.caapi microdosing is setting up is the fact that one of the functions that MAO enzymes have is metabolizing tyramine that we consume with several food products. Once we take b-carbolines / Inhibitors of monoamine oxidase we block the ability of enzymes to metabolize tyramine. If monoamine metabolism is compromised by the use of monoamine oxidase inhibitors (MAOIs) and foods high in tyramine are ingested, a threatening reactions such as hypertensive crisis can result, as tyramine also can displace stored monoamines, such as dopamine, norepinephrine, and epinephrine, from presynaptic vesicles. That is why it is essential to stick to a low tyramine diet while microdosing with b.caapi.
When using MAO inhibitor (MAOIs), an intake of approximately 10 to 25 mg of tyramine is required for a severe reaction, compared to 6 to 10 mg for a mild reaction.
To understand how strict our diet should be let's calculate the amount of tyramine in cheddar cheese. Due to the average content, we can trace 0,24mg of tyramine in 1 Gramm of cheddar cheese.
In this way to have a mild reaction, it is enough to eat only 25gr of cheddar cheese. As you can see during the course of microdosing with Ayahuasca we should change our diet to low tyramine.
Certain foods have high amounts of tyramine, especially foods that are:
• spoiled Specific foods with high tyramine content include:
• strong or aged cheeses like cheddar, blue cheese, or gorgonzola
• cured or smoked meats or fish, such as sausage or salami
• beers on tap or home-brewed
• some overripe fruits
• certain beans, such as fava or broad beans
• some sauces or gravies like soy sauce, teriyaki sauce, or bouillon-based sauces
• pickled products like sauerkraut
• sourdough breads
• fermented soy products like miso soup, bean curd, or tempeh; some forms of tofu are also fermented and should be avoided such as "stinky tofu" Below is a list of substances, that you should NOT take 12 hours before and 12 hours after taking MAO-inhibitors. Very dangerous:
Can cause headaches or sickness:
- migraine medicines
- allergy medicines
- over the counter cold medicines cocaine
- amphetamines (speed)
- MDMA (XTC)
- mescaline cacti (peyote and san pedro)
- ephedra/ephedrine (for example in products such as Ephedra Super caps, Super stacker, Ultra Boost)
- cultured dairy products (buttermilk, yogurt, and sour cream)
- all aged/mature cheese (exception: cottage cheese, cream cheese)
- dry and fermented sausage (bologna, salami, pepperoni, corned beef, and liver) all meat, fish and eggs which are not fresh
- pickled herring and salted dried fish
- meat extracts
- yeast extracts/brewer's yeast (Marmite)
- fruits (bananas, avocados, canned figs, raisins, red plums, pine-apple, raspberries) nuts (peanuts)
- broad beans and pods (lima, fava beans, lentils, snow peas, and soy beans) soyasauce
- LSA (morning glory and baby hawaiian woodrose seeds)
- MDA related herbs (nutmeg, sweet flag)
- caffeine (coffee, tea, cola, guarana, energy drinks)
- St Johns wort
- nasal sprays (Vicks Sinex, Prevalin or Otrivin)
- other MAO inhibitors.